本研究探討工作壓力和職場疲勞之現況及其關係，採用橫斷性研究設計進行結構式問卷收集研究資料，以台灣南部某化工廠為母群體，採用便利抽樣方式，發出350份問卷，回收有效問卷280份，有效問卷率達80%。問卷內容含基本資料、壓力量表和職場疲勞量表，所得資料以SPSS套裝軟體工具進行問卷處理與分析。結果顯示工作壓力與不同性別、教育程度、工作職稱、工作班別、平均每月薪資、平均每日睡眠時間和認為工作場所導致受傷可能性有顯著差異；職場疲勞與性別、年齡、教育程度、服務年資、工作班別、平均每月薪資、平均每日睡眠時間和認為工作場所導致受傷可能性有顯著差異。另工作壓力與職場疲勞具有顯著正相關，工作要求對整體職場疲勞、個人疲勞和工作疲勞均有最佳預測力。

The study was to investigate on the current situation and relationship between the work stress and occupational burnout of the employees. The design of cross-sectional study was applied to the collect the data by structured-questionnaire and to select the official employees of a chemical plant in southern Taiwan. The convenience sampling method was adopted by distributing 350 questionnaires and 280 effective questionnaires were collected which reached 80 % of the valid questionnaire recovery rate. The content of the questionnaires covered the basic information, stress scale, and occupational fatigue scale. All of the information and data collected were processed and analyzed by SPSS software tool. The results of the study showed there were statistically significant differences between work stress and different genders, educational levels, job titles, work shifts, average monthly salaries, daily sleep hours in average and possibility of employees’ injury at workplace first. Then there were significant differences between occupational burnout and genders, ages, educational levels, years of service, work shifts, average monthly salaries, daily sleep hours in average and possibility of employees’ injury at workplace. Finally, there is a positive correlation between work stress and occupational burnout and the work demand is the most important factors of occupational burnout.